On the other hand, I've been reading the web mostly via RSS feeds since at least that far back, and, as we all know, feeds can die quietly and mysteriously, while the underlying content keeps going, so we think something is gone - or, more often, don't notice or think about it - when it definitely isn't. And I'm pretty sure that I had C&H in my feeds, maybe multiple times, but I can't remember seeing it recently. So I think there was yet another case of linkrot, either deliberate (they want to drive people to their website, where other items can be purchased) or random (which can never been discounted).
But I noticed this book - Cyanide & Happiness: Twenty Years Wasted, a big anniversary collection of the strip published in mid-December, just too late for Xmas shipping. It's credited to "Kris, Rob & Dave" - Wilson, DenBleyker, and McElfatrick, respectively, the "Matt" who was part of C&H back in the early days seems to have dropped out long ago and gets one vague reference in this book but no explanation - and is the traditional "annotated collection of the best stuff" that strips often bring out for a big round anniversary.
And that's great, since that kind of book works better for webcomics than a traditional reprint anthology does, anyway. Remember: the point of a webcomic is that it's always accessible, online, 24/7/265. You can always just go there and read the entire archives, without buying a book. This book has fewer strips than if they were just packed in like cordwood, and getting the three creators to annotate them and laying that all out was clearly more work, but it makes a better, more distinctive, useful package. I don't want to say all webcomic collections should be in this style, but maybe all of the gag-a-day strips should seriously consider it.
Cyanide & Happiness has one of the weirder and odder origin stories, even for a webcomic. The four guys were all teens in 2005, hanging out on a webforum but hugely physically separated in real life - McElfratrick is Irish, for one example - and one of them did a quick crude comic in this style, and it snowballed from there. (They've also created a lot of animation over the years, and at least one card game - all with the same art style and deliberately offensive humor.) It looks like they spent some years in the same place: Dallas, as a suitable random American city. But that ended, for either pandemic or getting-older and lives-getting-more-complicated reasons, and they're once again physically separated, making comics and animation randomly in basements and back rooms wherever they happen to live now.
So each C&H strip is credited to one of the guys, because that guy did that strip. And their styles are somewhat discernable - or maybe were more so in the early days. But it's all the same kind of thing, and they riff off each other, with random theme weeks - usually either specifically Depressing comics or something tasteless - thrown in willy-nilly to pull them together.
These are jokes about farts and drinks and violence and sex and dicks and so on - the subject matter was mostly formed when they were teen boys, so C&H is still largely about the things that make teen boys laugh. (There were a lot of shitposts in the early days. Maybe still a few even now.) I thought it was mostly successful back in 2010, when I saw the early strips, and this big collection still seems mostly successful now - it's crude, it's tasteless, it's dumb, but there's always been a strong current of that kind of humor in America. (Think Truly Tasteless Jokes or 101 Uses for a Dead Cat or the one about how to fit five elephants into a Volkswagen.)
If you like that style of humor, you've probably seen Cyanide & Happiness sometime in the past twenty years. (Maybe not. Maybe you are a teen boy right now, and this is all new.) This is probably the best single book to experience the strip: it's got examples from all of the eras of the strip (such as they are), lots of annotations and added jokes, photos of the C&H guys doing various things at comics conventions over the past two decades, and similar stuff. Or, you know, you could just hit the website and read the archives, as I referenced way back at the beginning of this post. That's always an option for a webcomic; don't forget it.